HEY I was just gonna hit you up for some good ol' safehouse CR!!

I'd say maybe they're a little buddy-buddy? Not much gets to Amos in general but the compliance drugs are a massive trigger for him so he's still pretty on edge. Tewkesbury is like, the last person he's going to be violent towards so there's no worries there, but he's much less sure of himself in the safehouse and maybe more reliant on Tewkesbury for some emotional stability. So maybe treat him like he's a more outwardly damaged person because that's just where he's at right now.